EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database ,

ISSN 2394-3211

Impact Factor: 6.222

ICV - 79.57

Abstract

DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPLC METHOD FOR ESTIMATION OF SORAFENIB TOSYLATE

Mrinalini Damle*, Suresh Choudhari and Sanchita Kale

ABSTRACT

Simple, rapid validated stability indicating HPLC method for estimation of Sorafenib tosylate was successfully developed. The separation was achieved by using a mobile phase of Methanol: Water (pH 3 adjusted with Glacial Acetic Acid) in the ratio of 80:20 v/v using HiQ SiL C18 column (150 Ã— 4.6 mm i.d.5 Î¼m) at 1 ml/min as flow rate. The detection was carried out at 265 nm using PDA detector. The retention time observed was 5.5Â±0.2 min. This drug was subjected to stress conditions as per ICH Q1A (R2). Linearity was found to be in the concentration range of 10-50Î¼g/ml with r2 =0.9909. The suitability of this HPLC method for quantitative estimation of Sorafenib was proved by validation in accordance with requirements of ICH guidelines Q2A (R1).

Keywords: Sorafenib Tosylate, HPLC, Stress degradation, Validation, ICH guidelines.

[Full Text Article]

SJIF Impact Factor: 6.222

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New Issue Published
Its Our pleasure to inform you that, EJPMR 1 November 2023 Issue has been Published, Kindly check it on https://www.ejpmr.com/issue

EJPMR: NOVEMBER ISSUE PUBLISHED
November issue has been successfully launched on 1 November 2023

EJPMR New Impact Factor
Its our Pleasure to Inform you that EJPMR Impact Factor has been increased from 5.804 to 6.222, due to high quality Publication at International Level