EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

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 ICV - 79.57

Abstract

SUB-ACUTE TOXICITY AND GENOTOXICITY ASSESSMENT OF THE RHIZOME EXTRACT OF ACORUS CALAMUS L., A MEDICINAL PLANT OF INDIA

Purobi Nath, Arun K. Yadav* and Amar Deep Soren

ABSTRACT

The rhizomes of Acorus calamus L. have been used as a folk medicine against many diseases and disorders in India. This study assessed the sub-acute toxicity and genotoxicity potentials of A. calamus rhizome extract in Swiss albino mice. The mice were treated with a low (400 mg/kg) and a high (800 mg/kg) dose of A. calamus rhizome extract for 14 days. The sub-acute toxicity study analyzed the haematological, biochemical parameters, and histopathology of liver, kidney and spleen of animals. The genotoxicity assessement was done in vivo by chromosomal aberrations assay on bone marrow cells of mice. No mortality or behavioural adverse effects were observed in animals by 800 mg/kg oral dose of extract for 14 days. In biochemical assay, only 800 mg/kg dose revealed significant increase in alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total and direct bilirubins. No major effects were evident in any biochemical parameters by 400 mg/kg dose. In the haematological assay, only the high dose of extract showed significant increase in the numbers of neutrophils and lymphocytes, however, all blood parameters appeared normal in mice treated with 400 mg/kg dose of extract. The histopathological assessments of liver, kidney and spleen tissues also showed several deviations from their normal architectures only in the high dose treated group of animals. The genotoxic assessments revealed maximum frequencies of chromosomal aberrations in 800 mg/kg extract-treated animals. Taken together, this study suggested that 800 mg/kg dose of A. calamus rhizome extract may cause several toxic and genotoxic effects in experimental animals.

Keywords: Acorus calamus, folk medicine, genotoxicity, helminth parasite, histopathology, sub-acute toxicity.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )