EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

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 ISSN 2394-3211

Impact Factor: 6.222

 ICV - 79.57

Abstract

ECOFRIENDLY VALIDATED SPECTROPHOTOMETRIC METHODS FOR THE ESTIMATION OF AMLODIPINE BESYLATE IN PURE AND PHARMACEUTICAL FORMULATIONS USING HYDROTROPIC SOLUBILIZATION

Makka Hashim Ahmed*, Mohamed El-Mukhtar and A. E. M. Saeed

ABSTRACT

Simple sensitive and accurate spectrophotometric methods were developed for determination of poorly water
soluble Amlodipine Besylate (AML) in pure and pharmaceutical dosage form using three hydrotropic agents
ammonium acetate (method 1), potassium acetate (method 2) and nicotineamide (method 3). Hydrotropy is a good
choice for replacing organic solvents used for this kind of drugs to reduce the cost and hazards of the analytical
method. Amlodipine Besylate shows maximum absorption at 365 nm in 0.5 M of the three hydrotropic agents. All
hydrotropic agents did not show any absorbance above 250 nm so there is no interferences. Beer’s law was found
to be obeyed in the concentration range of 5 - 90 μg/mL for the three hydrotropes. Limit of detection was found to
be 1.072, 0.646 and 0.866 μg/mL and limit of quantification was 3.249, 1.956 and 2.625 μg/mL for ammonium
acetate, potassium acetate and nicotineamide, respectively. The results were in a good agreement with those
obtained with official USP method.

Keywords: Amlodipine Besylate, colorimetry, hydrotropy, method validation.


[Full Text Article]

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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process) IP Indexing (IP Value 2.40) Web of Science Group (Under Process) Directory of Research Journals Indexing Scholar Article Journal Index (SAJI) International Scientific Indexing ( ISI )