PHARMACEUTICAL ANALYTICAL APPROACHES FOR INOSINE PRANOBEX: A COMPREHENSIVE REVIEW

Geetha V.* and Vetrichelvan T.

ABSTRACT

Inosine Pranobex (IP), commonly known as inosine acedoben dimepranol, isoprinosine and methisoprinol, has been proven to positively impact the host’s immune system, by enhancing T-cell lymphocyte proliferation and activity of natural killer cells, increasing levels of pro-inflammatory cytokines and thereby restoring deficient responses in immunosuppressed patients. At the same time, it has been shown that it can affect viral RNA levels and hence inhibit growth of several viruses. Due to its immunomodulatory and antiviral properties, and its safety profile, it has been widely used since 1971 against viral infections and diseases, among which subacute sclerosis panencephalitis, herpes simplex virus, human papilloma virus, human immunodeficiency virus, influenza and acute respiratory infections, cytome - galovirus and Epstein–Barr virus infections. This article examines published analytical methods that are reported so far for the determination of inosine pranobex in Pharmaceutical formulations and biological samples. They include various techniques like high performance liquid chromatography (HPLC), Ultra performance liquid chromatography (UPLC), Liquid chromatography-mass chromatography (LC-MS), Hyphenated HPLC and tandem MS techniques and Thin layer chromatography (TLC).

Keywords: Inosine pranobex, Antiviral; Herpes; HPV; Immunomodulation; Infection; Influenza, Analytical methods.