IN-DEPTH ANALYSIS OF PREFORMULATION METHODS: A SCHOLARLY REVIEW IN DRUG DEVELOPMENT

Yash Parsewar, Muizz Kachhi*, Harshita Sachdev and Sagri Mane

ABSTRACT

In the world of pharmacy, individual drug internally has both chemical and physical attributes that have been taken into consideration before creating a pharmaceutical formulation. Preformulation is a topic of study that focuses on the physicochemical attributes of a new drug entity that could affect the development of the drug and the effectiveness of the dose form. Preformulation studies are conducted on newly synthesized or extracted compounds, and they provide information on the drug's toxicity, pharmacokinetics, bioavailability, and formulation of related compounds as well as the process of degradation. These qualities provide the framework for creating dosage forms by mixing drugs with pharmaceutical ingredients. Reformulation studies improve the public safety requirements, the product quality in the manufacture of dosage forms, regulatory relieving, and resource conservation in the improving the development of drug and review process. In this article, certain approaches and properties for preformulation evaluation parameters and medication manufacture are explained.

Keywords: Preformulation, Stability testing, Physio-Chemical properties, Polymorphism.