REVIEW ON BIOEQUIVALENCE STUDIES

Rajalakshmi P.*, Dr. Sakthivel M., Dr. Mohammed Halith, Akhilan A., Arivazhagan M., Manimegalai J. and Shafika Rishmana Sathik Basha

ABSTRACT

From this study, we can get a clear idea about how bioequivalence studies are being carried out. Different methods are being adopted for conducting bioequivalence studies, which helps the researchers gain good exposure to performing bioequivalence studies. In-vitro and in-vivo bioequivalence studies play a vital role in comparing the pharmacokinetic and pharmacodynamic activity of multi-brand generic molecules and in providing enough therapeutic activity of the dosage form. In this review article we have compiled the information on in-vitro bioequivalence studies and in vivo bioequivalence studies along with its importance and the various methods involved in these studies, which are suitable for both institutional and industrial practice as per the pharmacopoeial limits and requirements.

Keywords: Bioavailability, Bioequivalence, in-vitro & in-vivo studies, Pharmacokinetic parameters.