EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE  , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , 

 ISSN 2394- 3211

Impact Factor: 4.161

 ICV - 45.77

Abstract

PROCESSING OF BONE MARROW MONONUCLEAR STEM CELLS IN ACUTE SPINAL CORD INJURY

*Tulika Chandra MD., Dr. R.N.Srivastava MS., Dr. Saroj Chooramani Gopal Mch., S.Nishat Fatima Rizvi PhD Scholar., Devisha Agarwal MBBS Scholar

ABSTRACT

The present study was conducted to evaluate the concentration of MNCs and its CD 34 positive cell fraction in the infusion sample of the autologous bone marrow concentrate used in the SCI patients. Bone marrow was the first source of mononuclear stem cells for experimental and later for clinical use. For experimental use, it is still probably the best and most accessible. 44 patients with loss of motor and sensory functions due to injury between T6 and L3 skeletal levels were selected. Finding shows that middle age groups [Mean ± SD (Range) =32.70 ± 9.80] are more prone to the SCI. among all the mode of injuries, the direct fall from height is the most common one (57 %) and L1, L2 and T12 are three main levels of motor loss due to SCI. There was a significant positive correlation of the total volume of bone marrow aspirated with bone marrow derived mononuclear cells (p<0.01, r=0.92). The volume of bone marrow aspirated had a significant positive correlation with the number of bone marrow derived CD34+ cells (p<0.01, r=0.81). The total number of mononuclear cells had significant positive correlation with bone marrow derived CD34+ cells (p<0.01, r=0.78). No significant association was found between mononuclear cells and CD34+ cells count with age and sex of patients. We found that the number of mononuclear cells and CD34+ cells were higher if greater amount of volumes of bone marrow was aspirated hence improving the chances of recovery.

Keywords: SCI, CD34+, MNCs, BMC, BM.


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Google Scholar Indian Science Publications InfoBase Index (In Process) SOCOLAR, China Research Bible, Fuchu, Tokyo. JAPAN International Society for Research activity (ISRA) Scientific Indexing Services (SIS) Polish Scholarly Bibliography Global Impact Factor (GIF) (Under Process) Universal Impact Factor International Scientific Indexing (ISI), UAE Index Copernicus CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) UDLedge Science Citation Index CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Pubmed Database [NLM ID: 101669306] (Under Process)