CONSISTENT THERAPEUTIC OF THE DEPAKINE AND THE TEGRETOL AT THE EPILEPTICS BY THE DOSAGE OF THE CARBAMAZEPINE AND THE ACIDIC VALPROIQUE

Banza K. P.*, Kibulu K. J., Tshimbayi M. M., Koba B. B., Kayembe M. P. and Ndibualonji B. B.

ABSTRACT

The objective of our survey was to determine the concentrations plasmatic of the carbamazépine and the acidic valproïque respectively at the epileptics under treatment of Tégrétol and the dépakine and to value their concentrations plasmatic in relation to their therapeutic minimal concentrations in plasma. The concentrations middle plasmatic of the carbamazépine and the acidic valproïque that we got was respectively of 1,60 mg/l and 80,70 mg/l. In polythérapy the carbamazépine interacts with many medicines that make it inefficient or toxic. In polythérapie, the dépakine becomes inefficient or toxic insofar as the posology is not respected, but especially it enters in competition with the activation of the fatty acids in the transportation transmitochondrial. The addition of the carnitine to the epileptic treatment by the dépakine is a necessity to take in account and the dosage of the acidic valproïque and the carbamazépine.

Keywords: Consistent therapeutic, epilepsy, tegrétol, dépakine, carbamazépine, Valproïque acidic.