THE INFLUENCE OF SOME ENVIRONMENTAL POLLUTANTS ON THE HISTOGENESIS OF TEETH IN EXPERIMENTAL RATS

Kamilov Kh. P.* and Taylakova D. I.

ABSTRACT

The purpose of the work was to identify the features of embryonic development of rats as a whole, as well as embryonic and postnatal development of their dentoalveolar system under conditions of intrauterine exposure to some chemicals polluting the environment. Pesticides, hexachlorane and fosalone, as well as sulfur dioxide and nitrogen dioxide, which are the main components of harmful emissions from oil refineries, have been selected as polluting chemicals. The experiments were performed on non-matured mature white female rats with a body weight of 170-180 g.It is found that prenatal exposure of toxic substances (pesticides, sulfur and nitrogen dioxides) leads to impaired fetal and postnatal development of offspring, which are shown to the maximum extent in combined toxicity of pesticides and dioxides. It was also revealed that combined intrauterine intoxication substantially interferes with the tooth tissue differentiation and jaw bones of the fetus, resulting in the delayed eruption and abnormal development of the teeth in the postnatal period. Combined intrauterine intoxication significantly violates the processes of tissue differentiation of dental germ and ossification of the jaw bones of the fetus, which result in delayed eruption and abnormal development of teeth in the postnatal period.

Keywords: pesticides, dioxins, embryonic development, developmental dental toxicity, dental histogenesis, environmental toxicants.