SERUM CHOLECALCIFEROL IN BRONCHIAL ASTHMA AND ITS ASSOCIATION WITH ASTHMA SEVERITY

Dr. Vinesh Kumar*, Dr. Vikash kumar, Dr. Vijay Kumar, Dr. Sonia Sandeep, Dr. Arjan Dass and Dr. Vinesh Kumar

ABSTRACT

Objective: Determining the serum cholecalciferol in bronchial asthma and its association with asthma severity in adult patients. Study Design: Cross sectional study design. Place and Duration: Department of Medicine, Liaquat University Hospital, Hyderabad from March 2017 to May 2018. Subjects and Methods: 100 adults diagnosed of bronchial asthma and similar number of age and gender matched controls were analyzed for the serum cholecalciferol. Asthma severities were categorized as intermittent, mild, and moderate and sever persistent asthma. Serum cholecalciferol sufficiency, insufficiency and deficiency were defined as > 30 ng/mL), 20-30 ng/mL and < 20 ng/mL respectively. Serum cholecalciferol and serum IgE were detected from venous blood samples. Statistical software (SPSS v 22.0, IBM, Incorporation, USA) was used for data analysis at 95% confidence interval (P ≤ 0.05). Results: Serum cholecalciferol in controls was 38.19±15.67 ng/dl compared to 24.87±13.54 ng/dl in cases (P=0.0001). Severe cholecalciferol deficiency was noted in mild persistent asthma cases (17.90±6.51 ng/dl). Serum IgE, Eosinophils and Serum Cholecalciferol shows statistically significant differences between controls and cases (P<0.05). Serum cholecalciferol insufficiency and deficiency in controls was found in 51% compared to 85% in cases (P=0.0001) (table IV). Pearson`s correlation shows negative association of Serum Ig E (r= - 0.523**, p=0.0001) and blood eosinophils (r= - 0.629**, p=0.0001) with serum cholecalciferol. Conclusion: The present study found low serum cholecalciferol in bronchial asthma that shows negative correlation with asthma severity, serum IgE and blood eosinophils.

Keywords: Bronchial asthma, Serum cholecalciferol Serum IgE.