EVALUATION OF ANTIULCER ACTIVITY IN CANNA INDICA RHIZOMES

Mallikarjun Bere*, Rajesh Miryala, Srikanth Lingala, Chandramouli Golla and Naveen Chandra Kotagiri

ABSTRACT

With the rapid progress and advancement in various fields of human activities, the field of medicine and allied sciences has also made rapid strides. The synthesis of many chemicals and their introduction into therapeutics as drugs has certainly revolutionized the treatment of diseases. Peptic ulcer disease is a serious gastrointestinal disorder that requires a well targeted therapeutic strategy. A number of drugs including proton pump inhibitors and H2 receptor antagonists are available for the treatment of peptic ulcer, but clinical evaluation of these drugs has shown incidence of relapses, side effects and drug interactions. In an attempt to search a potent and safe medication for peptic ulcer, Canna indica rhizomes is being screened for its anti ulcer activity. Canna indica rhizomes were collected in Toopranpet village of Nalgonda district. Methanolic extraction method was used for extracting the active chemical constituents from plant materials. Acute toxicity study was carried out in male Swiss albino mice. MECI are considered to be safe up to the dose levels of 1000 mg/kg (b.w). By Asprin induced ulcer method, the standard drug of ranitidine showed 48.32% of ulcer inhibition. The % inhibition of 100 mg/kg, 200 mg/kg, and 400 mg/kg values are 19.35, 23.61, and 43.89 respectively. By Pyloric ligation induced ulcer method, the standard drug of ranitidine showed 79.23% of ulcer inhibition. The % inhibition of 100 mg/kg, 200 mg/kg, and 400 mg/kg values are 28.3, 53.46 and 65.45 respectively.

Keywords: Canna indica, Indian shot, Rhizomes Peptic ulcer and Herbal drugs.