SYNTHESIS, SPECTRAL STUDY AND BIOLOGICAL ACTIVITY OF SOME 2, 5–DISUBSTITUTED-1, 3, 4-OXADIAZOLE

Manpreet Kaur*, Satvir Singh and Mandeep Kaur

ABSTRACT

In the present article synthesis and evaluation for anticancer activity of a new series of 2,5-disubstituted-1,3,4-oxadiazole derivatives is described. 2,5-disubstituted-1,3,4-oxadiazole derivatives were synthesized by the reaction of Schiff bases derivatives with 2,5-disubstituted-1,3,4-oxadiazole. All the synthesized compounds were screened for their anticancer activity. 1,3,4-oxadiazoles are five membered heterocycles containing one oxygen and two nitrogen atoms at position 1, 3 and 4 position respectively. Five of the compounds possessed good to moderate anti-cancer activity. Three of the synthesized compounds i.e. 6a, 6f and 6g were found to possess maximum growth inhibition. The order for the % control growth inhibition of MCF-7 was found to be 6a>6f>6g>5b>6h as shown in Table no.6.1-6.7. The newly synthesized compounds were characterized on the basis of spectral (FT-IR, 1H NMR) analyses. All the synthesized compounds were found to be active against both the bacterial strain that is Gram negative bacteria Escherichia coli (MTCC 40) and Gram positive bacteria Staphylococcus aureus (MTCC 87), Bacillus subtilis (MTCC121). The zone of inhibition was observed in mm. Amongst all derivatives in series (5a-d), (6a-h) exhibited good antibacterial activity.

Keywords: 1, 3, 4- oxadiazole, Anticancer activity, Antimicrobial activity, Schiff bases.