DESIGN AND EVALUATION OF BUCCAL MUCOADHESIVE TABLETS OF PANTOPRAZOLE SODIUM
Swati Mittal* and Shalaka Pawar
ABSTRACT
Introduction: Drug delivery via buccal route using mucoadhesive dosage forms offers a novel route that can improve bioavailability of many drugs. Pantoprazole sodium is a proton pump inhibitor indicated for erosive esophagitis associated with gastroesophageal reflux disease (GERD). It is completely absorbed after oral administration, has short half life and low bioavailability because of first pass metabolism. It is a suitable candidate for administration via buccal route. Materials and methods: Various synthetic and natural bioadhesive polymers were studied for suitability as mucoadhesive buccal delivery. Bilayer mucoadhesive buccal tablets were prepared by direct compression. The tablets were evaluated for in vitro drug dissolution and ex vivo mucoadhesion. Results: Hydroxyl propyl methyl cellulose and sodium alginate were found to be most suitable mucoadhesive polymers. Drug release and ex vivo mucoadhesion was observed for 8 hours.
Keywords: buccal, mucoadhesive, esophagitis, hydroxyl propyl methyl cellulose, sodium alginate.
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