EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

SINGLE DOSE ACUTE ORAL TOXICITY OF LIVINA, A POLYHERBAL FORMULATION IN MICE MODEL

Soumendra Darbar* and Shyamaprasad Chattopadhyay

ABSTRACT

Acute toxicity studies are conducted to determine the short-term adverse effects of a drug when administered in a single dose, or in two or three times per day. It is used as a part of occupational health environmental impact assessments and batch release testing. The basic objective of the study is to evaluate the toxic effect of Livina, a polyherbal liquid formulation in mice. The study was conducted according to the guidelines of OECD. Swiss albino mice weighing between 20 and 35 gm were selected for the study. Livina in single oral dose (2000mg/kg) supplemented to all mice. The parameters like general appearance, behavior, body weight, mortality and necropsy were studied. No changes in general appearance and mortality was observed. Livina was found to be safe at dose of 2000mg/kg.

Keywords: Acute oral toxicity; Polyherbal Formulation; Livina; OECD guidelines, Necropsy.

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