ANTICANCER ACTIVITY OF METHANOLIC EXTRACT OF TEPHROSIA PURPUREA (LINN.) PERS LEAVES
P. Nagaveni*, G. Krishna Mohanand Switi B. Gaikwad
ABSTRACT
Tephrosia purpurea (Linn.) Pers belonging tofamily Fabaceae is a much branched, erect, perennialherb. It is commonly known as Sharapunkhain Sanskrit, Vempalli in Telugu, andWild Indigo in English. Traditionally, plant has been reported for the treatment of different ailments like anthelmintic, antipyretic, diseases of liver, spleen, heart, blood, tumours, ulcers, leprosy, asthma etc. According to Unani system of medicine, root is diuretic, enriches blood, and cures diarrhoea, useful in bronchitis, asthma, liver, spleen diseases, inflammations, pimples, piles, syphilis and gonorrhoea. Leaves are used as a tonic and a promising appetizer. Present study was an attempt to find out the anticancer potential of methanol extract of T. purpurea leaves for antimitotic activity by Allium cepa method and brine shrimp lethality test using Artemia salinaeggs.Results suggest that methanol extract (10 mg/ml) was found to possesscomparable antimitoticactivity withstandard drug Methotrexate (0.1 mg/ml) and for brine shrimp lethality test, 200 μg/ml of extract has shown significant activity.
Keywords: Tephrosia purpurea, Fabaceae, Sharapunkha, antimitotic, brine shrimp lethality test, Methotrexate.
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