PHYTOCHEMICAL AND PHARMACOLOGICAL RESEARCH ON PLANTS FROM THE GENUS PHOLIDOTA (ORCHIDACEAE)

Darshan Singh*, Satish Chandra Sati and Manisha Dobhal Sati

ABSTRACT

Ethnopharmacological Relevance: The plant of the genus Pholidota (Orchidaceae) is widely distributed, and have long been used in folk medicine for the treatment of various chronic bronchitis, toothache, treatment of dysentery, infections, asthma, bronchitis, eczema and duodenal ulcer, infections, rheumatism, cough suppressant, asthma, bronchitis, eczema inflammation, and muscular pain. Aim of the Review: In present review we emphasized the recent progress in the chemistry and biology this genus as well as its traditional uses. This database may provide guidance for researchers, chemists and herbologists for further investigation in the field Materials and Methods: All literature available on the genus Pholidota was collected via electronic search (using Scifinder, Google scholar,Scirus and Web of science ), books, thesis and journals. Results: Ethnobotanical uses of different species of genus Pholidota have been reported from China, Pakistan, India, tropical asia to tropical australia and Nepal for their different types of ailments,Genus Senecio possesses different chemical constituents including alkaloids, bibenzyls, stilbenes, phenolic compounds, and some other compounds.Crude extract, fraction, and isolated secondary metabolities of genus Pholidota have shown a wide range of pharmacological activities including antibacterial, antifungal, antiproliferative Effects, antioxidant , anti-Inflammatory and cholinesterase inhibiting activities. Conclusion: The leaves and roots of Pholidota plants have been used for the treatment of dysentery, conjunctivitis, infections, rheumatism, fever in the folk medicine system for years without any adverse effect. However there is a need to search for individual secondary metabolities responsible for these actions and study their mode of actions, and physiological pathways in sufficient details.

Keywords: Pholidota species P,articulata P. imbricata; P.yunnanensis Orchidaceae antiproliferative Effects.