ANTI-NOCICEPTIVE POTENTIALS OF METHANOLIC EXTRACT OF ARTOCARPUS ALTILIS (BREADFRUIT) ON CHEMICAL MODEL OF PAIN STUDY IN LABORATORY RODENTS
Ajah A. A.*, Amah-Tariah F. S. and Iwu I. C.
ABSTRACT
This study evaluates the anti-nociceptive potentials of methanolic extract of artocarpus altilis (breadfruit) on chemical model of pain study in laboratory rodents. The study was done using 25 albino wistar rats of both sexes, weighing 200-250g, using acetic acid induced writhing test as a chemical model of nociception. The LD50 value was determined as 3600mg/kg using Karber’s method. Standard doses were taken below the LD50 value as 100mg, 200mg and 300mg/kg of the plant extract. The rats were divided in five groups of five animals per group (both sexes). Group1 served as control group and were given 5ml of distilled water orally. Group 2, 3 and 4 were given methanolic extract of Artocarpus altilis in doses of 100mg, 200mg and 300mg/kg orally; and group 5 received 100mg/kg of aspirin orally, as a reference drug. Number of writhings in treated and control groups were compared. The result showed that methanolic extract of Artocarpus altilis seeds given orally caused significant (p < 0.05) analgesic effect on nociceptive response initiated by 0.6% acetic acid; although this analgesic effect was less than that produced by aspirin. Thus, it can be inferred that the methanolic extract of Artocarpus altilis possessed significant analgesic effect in rats.
Keywords: Artocarpus altilis, acetic acid, aspirin, chemical model, writhing.
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