TO EVALUATE THE HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC LEAF EXTRACT OF MORINGA OLEIFERA PLANT IN ALBINO WISTAR RATS.
Dr. Huzaif Shaikh*, Dr. Deepak Bhosle, Dr. Alimuddin Shaikh, Dr. Abhijeet Bhagat, Dr. Sameer Khan and Dr. Zubair Quazi
ABSTRACT
Introduction: Moringa Oleifera is widely found in Asian subcontinent and it has been used as an hepato-protective in Indian folklore medicine. In this study we compared the hepato- protective effects of Moringa Oleifera ethanolic extracts with other standard drug in Albino Wistar Rats. Methods: 30 Albino Wistar rats were divided into 5 groups of six each and administered placebo (saline), Liv-52 (standard) and 3 groups of Moringa Oleifera using 100mg/Kg, 200mg/Kg and 400mg/kg doses. Results: Rats treated with ethanolic Leaf extract of Moringa Oleifera (100/200/400 mg/kg, orally once daily) for 21days, the SGOT values (261.66±11.75 IU/L, 248.66±5.16 IU/L, 219±14.74 IU/L) were significantly lower (P<0.05), (P<0.05), (P<0.01) when compared to SGOT levels in control rats (277.00 ±7.45 IU/dl). Rats treated with ethanolic Leaf extract of Moringa Oleifera (100/200/400 mg/kg, orally once daily) for 21days, the SGPT values (72.33±4.96, 64.66±2.73, 56.33±2.33 IU/dl) were significantly lower (P<0.05), (P<0.05), (P<0.01) when compared to SGPT levels in control rats (99.33±2.65 IU/dl). Conclusion: Ethanolic extracts of Moringa Oleifera leaves exhibits significant hepatoprotective activity in a dose dependent manner.
Keywords: Hepatoprotective, Moringa Oleifera, SGOT, SGPT.
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