SERUM VITAMIN B12, FOLIC ACID, FERRITIN AND VITAMIN D LEVEL IN CELIAC DISEASE

Dr. Usha, *Anju Bharti, Shailza Singh, N. K. Agarwal, O. P. Mishra and Mohd. Frayez

ABSTRACT

Background: Celiac disease (CD) is very common in India. Recurrent diarrhoea and anaemia are most common manifestation. Main aim of present study was to find out prevalence of vitamin B12, Folic acid, Ferritin and Vitamin D3 so that their diet can be supplemented. Material & Methods: Study included 100 cases of CD and 22 healthy controls. Serum ferritin, vitamin B12, Folic acid and vitamin D were done by auto analyser (based on chemiluminiscent technique) of Artichet plus Abbott USA, Anti Tissue Transglutaminase Antibody(Anti Ttg) antibody was done by ELISA technique. Result: Our 60% patients were children between 2 to 16 years of age, 25% were adults and 21% were above 50 years. Failure to thrive and weight loss was more common manifestations (79%) followed by diarrhoea (71%), anaemia (66%) and pain abdomen (56%).Serum ferritin was significantly reduced in 50% patients and 21.4% controls. Majority of patients of CD had vitamin B12 level of 450- 550 pg/ml hence mean value was significantly reduced in CD patients (P. 000). Serum folic acid was reduced in 75% patients and 64.28% healthy controls. Mean value of Folic acid was not significantly reduced. Vitamin D levels were not affected in CD patients. Thus our study concludes that, serum ferritin and vitamin B12 are reduced in CD, while vitamin D is not affected. Hence CD diet must be supplemented with iron and vitamin B12.

Keywords: Celiac disease, serum ferritin, serum vitamin B12, serum folic acid, Nutritional deficiency in CD.