EUROPEAN JOURNAL OF
PHARMACEUTICAL AND MEDICAL RESEARCH

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical, Medical & Biological Sciences

An Official Publication of Society for Advance Healthcare Research (Reg. No. : 01/01/01/31674/16)

European Journal of Pharmaceutical and Medical Research (EJPMR) has indexed with various reputed international bodies like : Google Scholar , Indian Science Publications , InfoBase Index (In Process) , SOCOLAR, China , Research Bible, Fuchu, Tokyo. JAPAN , International Society for Research activity (ISRA) , Scientific Indexing Services (SIS) , Polish Scholarly Bibliography , Global Impact Factor (GIF) (Under Process) , Universal Impact Factor , International Scientific Indexing (ISI), UAE , Index Copernicus , CAS (A Division of American Chemical Society) USA (Under Process) , Directory of Open Access Journal (DOAJ, Sweden, in process) , UDLedge Science Citation Index , CiteFactor , Directory Of Research Journal Indexing (DRJI) , Indian citation Index (ICI) , Journal Index (JI, Under Process) , Directory of abstract indexing for Journals (DAIJ) , Open Access Journals (Under Process) , Impact Factor Services For International Journals (IFSIJ) , Cosmos Impact Factor , Jour Informatics (Under Process) , Eurasian Scientific Journal Index (ESJI) , International Innovative Journal Impact Factor (IIJIF) , Science Library Index, Dubai, United Arab Emirates , Pubmed Database [NLM ID: 101669306] (Under Process) , IP Indexing (IP Value 2.40) , Web of Science Group (Under Process) , Directory of Research Journals Indexing , Scholar Article Journal Index (SAJI) , International Scientific Indexing ( ISI ) , Scope Database , Academia ,

ISSN 2394-3211

Impact Factor: 7.065

ICV - 79.57

Abstract

PROTECTIVE EFFECT OF EMBLICA OFFICINALIS ON HISTOPATHOLOGICAL CHANGES IN RATS INDUCED WITH POTASSIUM DICHROMATE

Dr. Kader Asen Fathima* and Kalapuram Sivaraman Priyanka

ABSTRACT

Potassium dichromate is a common inorganic chemical reagent, most commonly used as an oxidizing agent in various laboratory and industrial applications. Prolonged exposure to the chemical causes hepatotoxicity, nephrotoxicity and oxidative stress damage of reproductive organs of both male and female. A single dose of Potassium dichromate (15mg/kg, b.w.i.p) dissolved in sterile saline (0.9% Nacl) induced histological alterations in liver, kidney and testis of male wistar rats. Pretreatment with Emblica officinalis at doses of 250 mg/kg body weight, prior to intoxication of Potassium dichromate prevented tissue damage. The results obtained in the study revealed the protective effect of Emblica officinalis.

Keywords: Potassium dichromate, Emblica officinalis, Hepatotoxicity, Nephrotoxicity, Testicular damage.

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