LIGATIONAL AND SPECTROSCOPIC ON SOME SULFAMETHOXAZOLE METAL COMPLEXES AS ANTIMICROBIAL AGENTS

Yasmin M.S. Jamil, Maher Ali Al-Maqtari* and Mohammed K. Al-Qadasi

ABSTRACT

Metal complexes have been applied as medicinal agents in the treatment of differenthuman infections and diseases. So, the aim of this study is focused on studying theligational, spectroscopic and evaluating antimicrobial investigations of sulfamethoxazole (SMX)drug complexes formulas with Mn (II), Cu (II), Ni (II), Zn (II), Y(III), La(III), Nd(III) and Gd(III) metal ions. These complexes with sulfamethoxazole ligand as to evaluate thebiological activity were synthesized and characterized by elemental analysis,molar conductance, magnetic susceptibility, UV-vis, IR and1H-NMR spectroscopy. The IR spectral data suggested that the coordination sites of SMX are the sulfonyloxygen and SO2-NH sulfonamide nitrogen as a bidentateligand ,from the microanalytical data, the stoichiometry of thecomplexes 1:2 (metal: ligand) was found, and the morphological nano structures of SMX complexes were checked using X-raypowder diffraction (XRD) and scanning electron microscope (SEM). The metal complexes werescreened for antibacterial activity against Gram-ve(Escherichia coli)(ATCC 8739) andGram+ve(Staphylococcus aureus)(ATCC 8739) and antifungal (Aspergillusflavus(ATCC 9643)and Aspergillusfumigatus(ATCC 1022)). These complexes considered in this research showed as a satisfactory antimicrobial activity.

Keywords: Sulfamethoxazole, lanthanides, nano size, antimicrobial activity.